|
เพิ่มความรุนแรงของโรค หรือลดประสิทธิภาพของ[[วัคซีนโควิด-19|วัคซีน]]<ref>{{Cite news | date = 2021-01-06 | title = Coronavirus variants and mutations: The science explained | language = en-GB | work = BBC News | url = https://www.bbc.com/news/science-environment-55404988 | access-date = 2021-02-02}}</ref><ref name=":6">{{Cite journal | last1 = Kupferschmidt | first1 = K | date = 2021-01-15 | title = New coronavirus variants could cause more reinfections, require updated vaccines | url = https://www.sciencemag.org/news/2021/01/new-coronavirus-variants-could-cause-more-reinfections-require-updated-vaccines | journal = Science | publisher = American Association for the Advancement of Science | doi = 10.1126/science.abg6028 | access-date = 2021-02-02}}</ref>
บทความนี้กล่าวถึงสายพันธุ์หรือรูปแปรที่โดดเด่นของ{{nowrap |ไวรัสโควิด-19}} และ[[การกลายพันธุ์]]แบบ{{nowrap |มิสเซนส์}} (missense mutation) ที่พบในสายพันธุ์เหล่านี้
== ความย่อ ==
แม้เชื้อ[[ไวรัสโควิด-19]] (SARS-CoV-2) เริ่มแรกอาจเกิดจากการผสมกัน (recombination) ระหว่างไวรัสคล้ายโควิดของค้างคาวกับไวรัสโคโรนาประจำ[[ตัวนิ่ม]] (ผ่านการติดต่อโรคข้ามสปีชีส์)<ref name="SARS-CoV-2 emergence due to recombination event">{{cite journal | last1 = Shahhosseini | first1 = Nariman | last2 = Wong | first2 = Gary | last3 = Kobinger | first3 = Gary | last4 = Chinikar | first4 = Sadegh | title = SARS-CoV-2 spillover transmission due to recombination event | journal = Gene Reports | date = 2021 | volume = 23 | page = 101045 | doi = 10.1016/j.genrep.2021.101045 | pmid = 33615041 | pmc = 7884226 }}</ref>
แต่[[การกลายพันธุ์]]ก็มีบทบาทสำคัญใน[[วิวัฒนาการ]]และการเกิดรูปแปรใหม่{{nbsp}}ๆ ของไวรัส<ref name="SARS-CoV-2 variants of concern"/>
สำหรับสายพันธุ์แรกที่ได้ตัวอย่างแล้วระบุใน[[ประเทศจีน]] นักวิจัยจัดว่ามันต่างกับ[[จีโนม]]บรรพบุรุษโดยห่างกันถึง {{nowrap |3 สายพันธุ์}}<ref name="progenitor_SARS-CoV-2">
{{Cite web | title = An evolutionary portrait of the progenitor SARS-CoV-2 and its dominant offshoots in COVID-19 pandemic | url = https://academic.oup.com/mbe/advance-article/doi/10.1093/molbev/msab118/6257226 | website = Oxford Academic | url-status = live | access-date = 2020-05-10 | first1 = Sudhir | last1 = Kumar | first2 = Qiqing | last2 = Tao | first3 = Steven | last3 = Weaver | first4 = Maxwell | last4 = Sanderford | first5 = Marcos A | last5 = Caraballo-Ortiz | first6 = Sudip | last6 = Sharma | first7 = Sergei L K | last7 = Pond | first8 = Sayaka | last8 = Miura}}</ref><ref name="SARS-CoV-2_ancestor">
{{Cite web | title = The ancestor of SARS-CoV-2's Wuhan strain was circulating in late October 2019 | url = https://www.news-medical.net/news/20210507/The-ancestor-of-SARS-CoV-2e28099s-Wuhan-strain-was-circulating-in-late-October-2019.aspx | website = News Medical | url-status = live | access-date = 2020-05-10 | quote = Journal reference: Kumar, S. et al. (2021). An evolutionary portrait...}}</ref>
ดังนั้น ไวรัสโควิด-19 จึงมีสายพันธุ์ต่าง{{nbsp}}ๆ มากมาย<ref name="pango-lineages">{{cite web | url = https://cov-lineages.org/lineages.html | title = Lineage descriptions | website = cov-lineages.org | publisher = Pango team}}</ref>
[[การหาลำดับดีเอ็นเอ]]ที่ทำกันได้ในปัจจุบันอาจทำให้ตรวจพบสายพันธุ์ใหม่{{nbsp}}ๆ ได้เร็วเมื่อโรคระบาด<ref>{{cite journal | last1 = Yurkovetskiy | first1 = Leonid | last2 = Wang | first2 = Xue | last3 = Pascal | first3 = Kristen E. | last4 = Tomkins-Tinch | first4 = Christopher | last5 = Nyalile | first5 = Thomas P. | last6 = Wang | first6 = Yetao | last7 = Baum | first7 = Alina | last8 = Diehl | first8 = William E. | last9 = Dauphin | first9 = Ann | last10 = Carbone | first10 = Claudia | last11 = Veinotte | first11 = Kristen | last12 = Egri | first12 = Shawn B. | last13 = Schaffner | first13 = Stephen F. | last14 = Lemieux | first14 = Jacob E. | last15 = Munro | first15 = James B. | last16 = Rafique | first16 = Ashique | last17 = Barve | first17 = Abhi | last18 = Sabeti | first18 = Pardis C. | last19 = Kyratsous | first19 = Christos A. | last20 = Dudkina | first20 = Natalya V. | last21 = Shen | first21 = Kuang | last22 = Luban | first22 = Jeremy | display-authors = 6 | title = Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant | journal = Cell | date = October 2020 | volume = 183 | issue = 3 | pages = 739-751.e8 | doi = 10.1016/j.cell.2020.09.032 | pmid = 32991842 | pmc = 7492024 }}</ref>
เมื่อใช้กับ[[โปรแกรมประยุกต์]]ที่แสดงต้นไม้สายพันธุ์โดยจำแนกตามวิวัฒนาการชาติพันธุ์ (phylogenetic tree visualization software) ลำดับจีโนมสามารถแบ่งเป็นกลุ่ม{{nbsp}}ๆ ที่มีการกลายพันธุ์แบบเดียวกัน
แต่ละกลุ่มเป็น 'variant', 'clade' หรือ 'lineage' และการเปรียบเทียบลำดับยีนก็จะทำให้รู้ถึงวิวัฒนาการของไวรัสได้
สำหรับไวรัสโควิด-19 งานศึกษาทางวิทยาการระบาดทั่วโลกได้ถอดลำดับยีนไวรัสเกิน {{nowrap |330,000 ลำดับ}}แล้ว<ref>{{cite journal | last1 = Thomson | first1 = Emma C. | last2 = Rosen | first2 = Laura E. | last3 = Shepherd | first3 = James G. | last4 = Spreafico | first4 = Roberto | last5 = da Silva Filipe | first5 = Ana | last6 = Wojcechowskyj | first6 = Jason A. | last7 = Davis | first7 = Chris | last8 = Piccoli | first8 = Luca | last9 = Pascall | first9 = David J. | last10 = Dillen | first10 = Josh | last11 = Lytras | first11 = Spyros | last12 = Czudnochowski | first12 = Nadine | last13 = Shah | first13 = Rajiv | last14 = Meury | first14 = Marcel | last15 = Jesudason | first15 = Natasha | last16 = De Marco | first16 = Anna | last17 = Li | first17 = Kathy | last18 = Bassi | first18 = Jessica | last19 = O’Toole | first19 = Aine | last20 = Pinto | first20 = Dora | last21 = Colquhoun | first21 = Rachel M. | last22 = Culap | first22 = Katja | last23 = Jackson | first23 = Ben | last24 = Zatta | first24 = Fabrizia | last25 = Rambaut | first25 = Andrew | last26 = Jaconi | first26 = Stefano | last27 = Sreenu | first27 = Vattipally B. | last28 = Nix | first28 = Jay | last29 = Zhang | first29 = Ivy | last30 = Jarrett | first30 = Ruth F. | last31 = Glass | first31 = William G. | last32 = Beltramello | first32 = Martina | last33 = Nomikou | first33 = Kyriaki | last34 = Pizzuto | first34 = Matteo | last35 = Tong | first35 = Lily | last36 = Cameroni | first36 = Elisabetta | last37 = Croll | first37 = Tristan I. | last38 = Johnson | first38 = Natasha | last39 = Di Iulio | first39 = Julia | last40 = Wickenhagen | first40 = Arthur | last41 = Ceschi | first41 = Alessandro | last42 = Harbison | first42 = Aoife M. | last43 = Mair | first43 = Daniel | last44 = Ferrari | first44 = Paolo | last45 = Smollett | first45 = Katherine | last46 = Sallusto | first46 = Federica | last47 = Carmichael | first47 = Stephen | last48 = Garzoni | first48 = Christian | last49 = Nichols | first49 = Jenna | last50 = Galli | first50 = Massimo | last51 = Hughes | first51 = Joseph | last52 = Riva | first52 = Agostino | last53 = Ho | first53 = Antonia | last54 = Schiuma | first54 = Marco | last55 = Semple | first55 = Malcolm G. | last56 = Openshaw | first56 = Peter J.M. | last57 = Fadda | first57 = Elisa | last58 = Baillie | first58 = J. Kenneth | last59 = Chodera | first59 = John D. | last60 = Rihn | first60 = Suzannah J. | last61 = Lycett | first61 = Samantha J. | last62 = Virgin | first62 = Herbert W. | last63 = Telenti | first63 = Amalio | last64 = Corti | first64 = Davide | last65 = Robertson | first65 = David L. | last66 = Snell | first66 = Gyorgy | display-authors = 6 | title = Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity | journal = Cell | date = March 2021 | volume = 184 | issue = 5 | pages = 1171-1187.e20 | doi = 10.1016/j.cell.2021.01.037 | pmid = 33621484 | pmc = 7843029 }}</ref>
SARS-CoV-2 กำลังวิวัฒนาการทำให้ติดต่อได้ง่ายขึ้น ที่เด่นก็คือสายพันธุ์[[#อัลฟา|อัลฟา]]และ[[#เดลตา|เดลตา]]ซึ่งติดต่อได้ง่ายกว่าไวรัสดั้งเดิมที่พบในอู่ฮั่น<ref>{{cite news | title = Covid: Is there a limit to how much worse variants can get? | date = 2021-06-12 | url = https://www.bbc.co.uk/news/health-57431420 | work = BBC }}</ref>
ตารางต่อไปนี้แสดงข้อมูลและความเสี่ยงของสายพันธุ์ที่เสี่ยงเพิ่มหรืออาจเสี่ยงเพิ่มในปัจจุบัน<ref name="who-variants">
{{Cite web | title = Tracking SARS-CoV-2 variants | url = https://www.who.int/en/activities/tracking-SARS-CoV-2-variants/ | url-status = live | website = who.int | language = en | publisher = World Health Organization | archive-url = https://web.archive.org/web/20210618122320/https://www.who.int/en/activities/tracking-SARS-CoV-2-variants/ | archive-date = 2021-06-18}}</ref><ref name="cdc-variants">
{{cite web | url = https://www.cdc.gov/coronavirus/2019-ncov/variants/variant-info.html | title = SARS-CoV-2 Variant Classifications and Definitions | website = CDC.gov | date = 2020-02-11 | publisher = Centers for Disease Control and Prevention}}</ref><ref name="phe-voc">
{{cite web | url = https://www.gov.uk/government/publications/covid-19-variants-genomically-confirmed-case-numbers/variants-distribution-of-cases-data | title = Variants: distribution of cases data | website = GOV.UK | publisher = Government Digital Service | agency = Public Health England}}</ref><ref name="aci-variants">
{{cite web | url = https://aci.health.nsw.gov.au/covid-19/critical-intelligence-unit/sars-cov-2-variants | title = Living Evidence - SARS-CoV-2 variants | website = nsw.gov.au | date = 2021-06-22 | publisher = Ministry of Health (New South Wales) | department = Agency for Clinical Innovation}}</ref><ref name="ecdc-variants">
{{cite web | title = SARS-CoV-2 variants of concern | url = https://www.ecdc.europa.eu/en/covid-19/variants-concern | website = ECDC.eu | publisher = European Centre for Disease Prevention and Control}}</ref><ref name="who-situation">
{{cite web | title = Coronavirus Disease (COVID-19) Situation Reports | url = https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports | website = who.int | publisher = World Health Organization}}</ref><ref name="phe-briefings">
{{cite web | title = Investigation of SARS-CoV-2 variants of concern: technical briefings | url = https://www.gov.uk/government/publications/investigation-of-novel-sars-cov-2-variant-variant-of-concern-20201201 | website = GOV.UK | publisher = Government Digital Service | agency = Public Health England}}</ref><ref name="phe-variant-risk">
{{cite web | title = Investigation of SARS-CoV-2 variants of concern: variant risk assessments | url = https://www.gov.uk/government/publications/investigation-of-sars-cov-2-variants-of-concern-variant-risk-assessments | website = GOV.UK | publisher = Government Digital Service | agency = Public Health England}}</ref>
ช่วงพิสัยมีความเชื่อมั่น{{nowrap |[[ร้อยละ]] 95}} ยกเว้นจะระบุต่างหาก
ให้สังเกตว่าเลขเหล่านี้เป็นค่าประมาณทั้งหมดเพราะข้อมูลการศึกษามีจำกัด
;ระดับความเสี่ยงโดยเปรียบเทียบ<ref>{{cite web | title = SARS-CoV-2 variants: risk assessment framework | id = GOV-8426 | url = https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/988614/Risk_assessment_framework_for_SARS-CoV-2_variants_20210521.pdf | format = PDF | website = GOV.UK | publisher = Government Digital Service | agency = Public Health England | date = 2021-05-22}}
</ref> {{Legend inline |#faa|สูงมาก}} {{Legend inline |#fc8|สูง}} {{Legend inline |#fe8|ปานกลาง}} {{Legend inline |#cfc|ต่ำ}} {{Legend inline |#eee|ไม่ชัดเจน}}
{| class="wikitable sortable"
! colspan="4" |การระบุ<ref name="who-update-latest">{{cite techreport | type = Situation report | title = Weekly epidemiological update on COVID-19 - 15 June 2021 | institution = World Health Organization | date = 2021-06-15 | url = https://www.who.int/publications/m/item/weekly-epidemiological-update-on-covid-19---15-june-2021 | access-date = 2021-06-16}}</ref>
! colspan="3" |การเกิด
! colspan="8" |ความเปลี่ยนแปลงเทียบกับสายพันธุ์ที่มีมาก่อน ณ เวลาและสถานที่ที่เกิด
|-
!องค์การอนามัยโลก
!แพงโก<wbr />{{efn-ua | name = PANGO | Phylogenetic Assignment of Named Global Outbreak Lineages (PANGO) lineage }}
!พีเอชอี<wbr />{{efn-ua |Public Health England (PHE) variant - รูปแบบการตั้งชื่อได้อัปเดตเมื่อเดือนมีนาคม 2021 โดยเปลี่ยนปีจากเลข 4 หลักเหลือ 2 หลัก และเปลี่ยนเดือนจากเลข 2{{nbsp}}หลักเป็นอักษรย่อ 3{{nbsp}}ตัว ตัวอย่างเช่น ดั้งเดิมเป็น VOC-'''2021'''''01''-02 ให้เปลี่ยนเป็น VOC-'''21'''''JAN''-02<ref name="phe-voc" />}}
!{{nowrap |เน็กซต์}}{{nowrap |สเตรน}}<wbr />{{efn-ua | name = Nextstrain | Nextstrain clade }}
!ระบาดครั้งแรก
!ตัวอย่างแรกสุด<wbr /><ref name="who-update-latest"/>
!เมื่อระบุว่าน่าเป็นห่วง
![[การกลายพันธุ์]]ที่เด่น
![[ค่าระดับการติดเชื้อพื้นฐาน|การติดต่อได้]]
!การเข้า รพ.
!อัตราการตาย
!ความแม่นยำของการตรวจ
![[แอนติบอดีลบล้างฤทธิ์|ภูมิคุ้มกันไม่ให้ติดเชื้อได้อีก]]<wbr />{{efn-ua | name = neutralization-efficacy |
ถ้าไม่ได้ระบุไว้โดยเฉพาะ นี่ปกติหมายถึงภูมิในน้ำเหลืองคือ neutralizing antibody ซึ่งมี[[สหสัมพันธ์]]กับภูมิคุ้มกันโรค
งานศึกษาโดยมากยังไม่ได้ระบุผลจริง{{nbsp}}ๆ ของภูมิที่ลดลงต่อค่า[[ประสิทธิศักย์ของวัคซีน]]
}}
![[ประสิทธิศักย์ของวัคซีน]]<wbr />{{efn-ua | name = neutralization-efficacy}}
!ประสิทธิศักย์ของสารภูมิต้านทานแบบโมโนโคลน<wbr />{{efn-ua |Monoclonal antibody efficacy}}<ref name="cdc-variants"/>
|-
|{{sort |1|[[#อัลฟา|อัลฟา]]}}
|B.1.1.7
|VOC‑20DEC‑01<wbr />
|20I (V1)
|[[สหราชอาณาจักร]]
|{{dts |2020|09|20 | format = dmy | abbr = on}}<wbr/><ref>{{cite web | last1 = Rambaut | first1 = A | last2 = Loman | first2 = N | last3 = Pybus | first3 = O | last4 = Barclay | first4 = W | last5 = Barrett | first5 = J | last6 = Carabelli | first6 = A | last7 = Connor | first7 = T | last8 = Peacock | first8 = T | last9 = Robertson | first9 = DL | last10 = Volz | first10 = E | display-authors = 6 | date = 2020-12-18 | title = Preliminary genomic characterisation of an emergent SARS-CoV-2 lineage in the UK defined by a novel set of spike mutations | url = https://virological.org/t/preliminary-genomic-characterisation-of-an-emergent-sars-cov-2-lineage-in-the-uk-defined-by-a-novel-set-of-spike-mutations/563 | access-date = 2021-06-14 | website = Virological}}</ref>
|{{dts |2020|12|18 | format = dmy | abbr = on}}<wbr/><ref>{{cite techreport | type = Briefing | title = Investigation of novel SARS-COV-2 variant, technical briefing 1 | institution = Public Health England | date = 2020-12-21 | url = https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/959438/Technical_Briefing_VOC_SH_NJL2_SH2.pdf | format = PDF | access-date = 2021-06-06}}</ref>
|69-70del, N501Y, P681H<wbr /><ref name=":33">{{cite web | date = 2021-01-28 | title = Emerging SARS-CoV-2 Variants | url = https://www.cdc.gov/coronavirus/2019-ncov/more/science-and-research/scientific-brief-emerging-variants.html | access-date = 2021-01-04 | website = CDC.gov | publisher = Centers for Disease Control and Prevention | type = Science brief}} {{PD-notice}}</ref>{{sfnp |Chand ''et al.''|2020 | p = 6 | loc = Potential impact of spike variant N501Y}}
|{{risk | level = veryhigh | align = ml|{{Estimate |+82|43|130 | unit = % | type = cri | mini = auto}}<wbr/>{{efn-ua | name = alpha-transmissibility|1 มีค. - 24 ธค. 2020 ประเทศอังกฤษ<ref name="pmid33658326">{{cite journal | author = Davies, NG; Abbott, S; Barnard, RC; Jarvis, CI; Kucharski, AJ; Munday, JD | display-authors = etal | title = Estimated transmissibility and impact of SARS-CoV-2 lineage B.1.1.7 in England. | journal = Science | year = 2021 | volume = 372 | issue = 6538 | pages = eabg3055 | pmid = 33658326 | doi = 10.1126/science.abg3055 | pmc = 8128288 }}</ref>}}}}
|{{risk | level = veryhigh | align = ml|{{Estimate |+52|47|57 | unit = % | mini = auto}}<wbr/>{{efn-ua | name = alpha-severity|23 พย. 2020 - 31 มค. 2021 ประเทศอังกฤษ<ref>{{cite journal | last1 = Nyberg | first1 = T | last2 = Twohig | first2 = KA | last3 = Harris | first3 = RJ | last4 = Seaman | first4 = SR | last5 = Flannagan | first5 = J | last6 = Allen | first6 = H | last7 = Charlett | first7 = A | last8 = Angelis | first8 = D | last9 = Dabrera | first9 = G | last10 = Presanis | first10 = AM | display-authors = 6 | date = 2021-06-15 | title = Risk of hospital admission for patients with SARS-CoV-2 variant B.1.1.7: cohort analysis | url = https://www.bmj.com/content/373/bmj.n1412 | journal = BMJ | volume = 373 | pages = n1412 | doi = 10.1136/bmj.n1412 | issn = 1756-1833 | pmid = 34130987 | s2cid = 235187479 }}</ref>}}}}
|{{risk | level = veryhigh | align = ml|{{Estimate |+59|44|74 | unit = % | mini = auto}}<wbr/>{{efn-ua | name = alpha-severity}}}}
|{{risk | level = low | align = ml|ไม่เปลี่ยน<wbr/><ref name="aci-variants"/>}}
|{{risk | level = low | align = ml|ลดลงน้อย<wbr/><ref name="cdc-variants"/>}}
|{{risk | level = low | align = ml|ลดลงน้อย<wbr/><ref name="cdc-variants"/>}}
|{{risk | level = low | align = ml|ไม่เปลี่ยน}}
|-
|{{sort |2|[[#เบตา|เบตา]]}}
|B.1.351
|VOC‑20DEC‑02
|20H (V2)
|[[แอฟริกาใต้]]
|{{dts |2020|05 | format = dmy | abbr = on}}
|{{dts |2021|01|14 | format = dmy | abbr = on}}<wbr/><ref>{{cite techreport | type = Note | title = NERVTAG paper: brief note on SARS-CoV-2 variants | institution = Public Health England | date = 2021-01-13 | last1 = Horby | first1 = Peter | last2 = Barclay | first2 = Wendy | last3 = Huntley | first3 = Catherine | url = https://www.gov.uk/government/publications/nervtag-brief-note-on-sars-cov-2-variants-13-january-2021 | access-date = 2021-06-06}}</ref>
|K417N, E484K, N501Y<wbr /><ref name=":33"/>
|{{risk | level = veryhigh | align = ml|{{Estimate |+52|46|58 | unit = % | mini = auto}}<wbr/>{{efn-ua |1 สค. - 31 ธค. 2020 [[สหราชอาณาจักร]]<ref>{{cite journal | last1 = Zhao | first1 = S | last2 = Lou | first2 = J | last3 = Cao | first3 = L | last4 = Zheng | first4 = H | last5 = Chong | first5 = MK | last6 = Chen | first6 = Z | last7 = Chan | first7 = RN | last8 = Zee | first8 = BC | last9 = Chan | first9 = PK | last10 = Wang | first10 = MH | display-authors = 6 | date = 2021-01-28 | title = Quantifying the transmission advantage associated with N501Y substitution of SARS-CoV-2 in the UK: an early data-driven analysis | url = https://doi.org/10.1093/jtm/taab011 | journal = Journal of Travel Medicine | volume = 28 | issue = 2 | doi = 10.1093/jtm/taab011 | issn = 1195-1982 | pmc = 7928809 | pmid = 33506254}}</ref>
ส่วนงานศึกษาอีกงานหนึ่งพบค่าที่ {{Estimate |+50|20|113 | unit = % | type = cri | mini = auto}} ในแอฟริกาใต้ระหว่างเดือน พค. - พย. 2020<ref name="ECDC1">{{cite techreport | type = Risk assessment | title = Risk related to the spread of new SARS-CoV-2 variants of concern in the EU/EEA - first update | url = https://www.ecdc.europa.eu/en/publications-data/covid-19-risk-assessment-spread-new-variants-concern-eueea-first-update | institution = European Centre for Disease Prevention and Control | date = 2021-02-02}}</ref>}}}}
|{{risk | level = unknown | align = ml|''กำลังตรวจสอบ''}}
|{{risk | level = medium | align = ml|อาจเพิ่ม<wbr/><ref name="aci-variants"/><ref name="who-update-8june">{{cite techreport | type = Situation report | title = Weekly epidemiological update on COVID-19 - 8 June 2021 | institution = World Health Organization | date = 2021-06-08 | url = https://www.who.int/publications/m/item/weekly-epidemiological-update-on-covid-19---8-june-2021 | access-date = 2021-06-14}}</ref>}}
|{{risk | level = low | align = ml|ไม่เปลี่ยน<wbr/><ref name="aci-variants"/>}}
|{{risk | level = medium | align = ml|ลดลงแต่การตอบสนองของเซลล์ทีต่อไวรัส D614G ยังคงประสิทธิภาพ<wbr/><ref name="cdc-variants"/><ref name="who-update-8june"/>}}
|{{risk | level = veryhigh | align = ml|ลด[[ประสิทธิศักย์ของวัคซีน|ประสิทธิศักย์วัคซีน]]หลายอย่าง<wbr/>{{efn-ua |ยกเว้น[[วัคซีนโควิด-19 ของโมเดอร์นา|วัคซีนของโมเดอร์นา]]และ[[วัคซีนโควิด-19 ของจอห์นสันแอนด์จอห์นสัน|จอห์นสัน]]<ref name="aci-variants"/><ref name="who-update-8june"/>}}}}
|{{risk | level = low | align = ml|บางอย่างยังคงประสิทธิศักย์อยู่}}
|-
|{{sort |3|[[#แกมมา|แกมมา]]}}
|P.1
|VOC‑21JAN‑02
|20J (V3)
|[[บราซิล]]
|{{dts |2020|11 | format = dmy | abbr = on}}
|{{dts |2021|01|15 | format = dmy | abbr = on}}<ref>
{{cite news | title = Confirmed cases of COVID-19 variants identified in UK | location = Friday 15 January | url = https://www.gov.uk/government/news/confirmed-cases-of-covid-19-variants-identified-in-uk | agency = Public Health England | publisher = GOV.UK | date = 2021-01-15}}</ref><ref>
{{cite techreport | last1 = Horby | first1 = Peter | last2 = Barclay | first2 = Wendy | last3 = Gupta | first3 = Ravi | last4 = Huntley | first4 = Catherine | type = Note | title = NERVTAG paper: note on variant P.1 | institution = Public Health England | date = 2021-01-27 | url = https://www.gov.uk/government/publications/nervtag-note-on-variant-p1-27-january-2021 | access-date = 2021-06-06}}</ref>
|K417T, E484K, N501Y<wbr /><ref name=":33"/>
|{{risk | level = veryhigh | align = ml|{{Estimate |+161|145|176 | unit = % | mini = auto}}<wbr/>{{efn-ua |1 พย. 2020 - 31 มค. 2021, [[มาเนาส์]]<ref>{{cite document | last1 = Coutinho | first1 = RM | last2 = Marquitti | first2 = FM | last3 = Ferreira | first3 = LS | last4 = Borges | first4 = ME | last5 = da Silva | first5 = RL | last6 = Canton | first6 = O | last7 = Portella | first7 = TP | last8 = Lyra | first8 = SP | last9 = Franco | first9 = C | last10 = Plucinski | first10 = MM | last11 = Lessa | first11 = FC | display-authors = 6 | date = 2021-03-23 | title = Model-based estimation of transmissibility and reinfection of SARS-CoV-2 P.1 variant | url = https://www.medrxiv.org/content/10.1101/2021.03.03.21252706v3 | work = medRxiv | type = Preprint | doi = 10.1101/2021.03.03.21252706 | page = 9 | s2cid = 232119656 | quote = The new variant was found to be about 2.6 times more transmissible (95% Confidence Interval (CI): 2.4-2.8) than previous circulating variant (s). ... Table 1: Summary of the fitted parameters and respective confidence intervals considering the entire period, November 1, 2020-January 31, 2021 maintaining the same pathogenicity of the previous variant. Parameter: Relative transmission rate for the new variant. Estimate: 2.61. 2.5%: 2.45. 97.5%: 2.76. | access-date = 2021-04-29}}</ref>
งานศึกษาอีกงานหนึ่งในมาเนาสประเมินว่าสายพันธุ์ P.1 อาจติดต่อได้ง่ายกว่า {{Estimate |100|70|140|50 | unit = % | type = cri | mini = auto}}{{efn-ua | name = low-confidence}}<ref name="cadde-p1"/>}}}}
|{{risk | level = medium | align = ml|อาจเพิ่ม<wbr/><ref name="who-update-8june"/>}}
|{{risk | level = high | align = ml|{{Estimate |+50|20|90|50 | unit = % | type = cri | mini = auto}}{{efn-ua | name = low-confidence|
ช่วงความเชื่อมั่นที่รายงานมี[[ความน่าจะเป็น]]ต่ำ ดังนั้น ค่าประมาณจึงจัดว่าแค่เป็นไปได้ แต่ก็ยังไม่แน่นอนหรือว่า น่าจะใช่
}}{{efn-ua |
มีค. 2020 - กพ. 2021 มาเนาส์<ref name="cadde-p1" />
ผลเบื้องต้นจากงานศึกษาหนึ่งในเขตทิศใต้ของบราซิลพบว่า สายพันธุ์ P.1 ทำให้คนอายุน้อยและมีสุขภาพดีถึงตายยิ่งกว่า
ในกลุ่มที่ไร้โรคประจำตัว สายพันธุ์นี้พบว่าทำให้ชายอายุ {{nowrap |20-39 ปี}}ถึงตายยิ่งกว่า {{Estimate |490|220|985 | unit = % | prefix = sym | mini = auto}},
หญิงอายุ {{nowrap |20-39 ปี}}ถึงตายยิ่งกว่า {{Estimate |465|190|1003 | unit = % | prefix = sym | mini = auto}}
และหญิงอายุ {{nowrap |40-59 ปี}}ถึงตายยิ่งกว่า {{Estimate |670|401|1083 | unit = % | prefix = sym | mini = auto}}<ref>{{cite journal | last1 = Freitas | first1 = AR | last2 = Lemos | first2 = DR | last3 = Beckedorff | first3 = OA | last4 = Cavalcanti | first4 = LP | last5 = Siqueira | first5 = AM | last6 = Mello | first6 = RC | last7 = Barros | first7 = EN | display-authors = 6 | date = 2021-04-19 | title = The increase in the risk of severity and fatality rate of covid-19 in southern Brazil after the emergence of the Variant of Concern (VOC) SARS-CoV-2 P.1 was greater among young adults without pre-existing risk conditions | url = https://www.medrxiv.org/content/10.1101/2021.04.13.21255281v1 | type = Preprint | via = medRxiv | doi = 10.1101/2021.04.13.21255281 | quote = Female 20 to 39 years old, with no pre-existing risk conditions, were at risk of death 5.65 times higher in February (95% CI, 2.9-11.03; p <0.0001) and in the age group of 40 and 59 years old, this risk was 7.7 times higher (95% CI, 5.01-11.83; p <0.0001) comparing with November-December. ... The heterogeneity observed between the age groups was greater when we analyzed the subgroup of the population without preexisting risk conditions where we found that the CFR in the female sex in the second wave was 1.95 times (95% CI, 1.38-2.76) the CFR of the first wave in the population over 85 years old and was 7.7 times (95% CI, 5.01-11.83; p < 0.0001) in the population between 40 and 59 years old. In the male population without previous diseases, the CFR in the second wave was 2.18 (95% CI, 1.62-2.93) times the CFR of the first wave in the population over 85 years old and 5.9 (95% CI, 3.2-10.85; p < 0, 0001) higher in the range between 20 and 39 years old.}}</ref>{{efn-ua | name = different-conditions}}}}}}
|{{risk | level = low | align = ml|ไม่เปลี่ยน<ref name="aci-variants"/>}}
|{{risk | level = medium | align = ml|ลดลง<ref name="cdc-variants"/>}}
|{{risk | level = low | align = ml|หลายชนิดยังคงประสิทธิศักย์<wbr/>{{efn-ua |ยกเว้น[[วัคซีนโควิด-19 ของไฟเซอร์-ไบออนเทค|วัคซีนของไฟเซอร์-ไบออนเทค]]<ref name="aci-variants"/>}}}}
|{{risk | level = low | align = ml|บางชนิดยังคงประสิทธิศักย์}}
|-
|{{sort |1.1|[[#อัลฟา|อัลฟา]]}}
|อัลฟาบวกกับ [[E484K]]<ref name="PHE2102">{{Cite web | last = Public Health England | date = 2021-02-16 | title = Variants: distribution of cases data | url = https://www.gov.uk/government/publications/covid-19-variants-genomically-confirmed-case-numbers/variants-distribution-of-cases-data | url-status = live | access-date = 2021-02-17 | website = GOV.UK}}</ref>
|VOC‑21FEB‑02
|20I (V1)
|[[สหราชอาณาจักร]]
|{{dts |2021|01|26 | format = dmy | abbr = on}}<ref>{{cite techreport | type = Briefing | title = Investigation of novel SARS-CoV-2 variant 202012/01, technical briefing 5 | id = GW-1905 | institution = Public Health England | date = 2021-02-02 | url = https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/959426/Variant_of_Concern_VOC_202012_01_Technical_Briefing_5.pdf | format = PDF | access-date = 2021-06-14}}</ref>
|{{dts |2021|02|05 | format = dmy | abbr = on}}<ref name="GW-1934">{{cite techreport | type = Briefing | title = Investigation of SARS-CoV-2 variants of concern in England, technical briefing 6 | id = GW-1934 | institution = Public Health England | date = 2021-02-13 | url = https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/961299/Variants_of_Concern_VOC_Technical_Briefing_6_England-1.pdf | format = PDF | access-date = 2021-06-06}}</ref>
|69-70del, E484K, N501Y, P681H<ref name=":33"/>{{sfnp |Chand ''et al.''|2020 | p = 6 | loc = Potential impact of spike variant N501Y}}
|{{risk | level = veryhigh | align = ml|{{Estimate |+82|43|130 | unit = % | type = cri | mini = auto}}<wbr/>{{efn-ua | name = same-alpha|
สมมุติว่าเท่ากับอัลฟา<ref name="ecdc-variants"/>}}{{efn-ua | name = alpha-transmissibility}}}}
|{{risk | level = veryhigh | align = ml|{{Estimate |+52|47|57 | unit = % | mini = auto}}{{efn-ua | name = same-alpha}}
{{efn-ua | name = alpha-severity}}}}
|{{risk | level = veryhigh | align = ml|{{Estimate |+59|44|74 | unit = % | mini = auto}}{{efn-ua | name = same-alpha}}{{efn-ua | name = alpha-severity}}}}
|{{risk | level = low | align = ml|ไม่เปลี่ยน<wbr/>{{efn-ua | name = same-alpha}}}}
|{{risk | level = high | align = ml|ลดลงอย่างสำคัญ<ref name="b117e484k"/>}}
|{{risk | level = high | align = ml|ลดลงอย่างสำคัญ<ref name="b117e484k">{{cite journal | last1 = Collier | first1 = DA | last2 = De Marco | first2 = A | last3 = Gupta | first3 = RK | last4 = al | first4 = et | title = Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies. | doi = 10.1038/s41586-021-03412-7 | date = 2021-05-06 | journal = Nature | volume = 593 | issue = 7857 | pages = 136-141 | pmid = 33706364 | type = Published | quote = We therefore generated pseudoviruses that carried the B.1.1.7 spike mutations with or without the additional E484K substitution and tested these against sera obtained after the first and second dose of the BNT162b2 mRNA vaccine as well as against convalescent sera. After the second vaccine dose, we observed a considerable loss of neutralizing activity for the pseudovirus with the B.1.1.7 spike mutations and E484K (Fig. 3d, e). The mean fold change for the E484K-containing B.1.1.7 spike variant was 6.7 compared with 1.9 for the B.1.1.7 variant, relative to the wild-type spike protein (Fig. 3a-c and Extended Data Fig. 5). Similarly, when we tested a panel of convalescent sera with a range of neutralization titres (Fig. 1f, g and Extended Data Fig. 5), we observed additional loss of activity against the mutant B.1.1.7 spike with E484K, with fold change of 11.4 relative to the wild-type spike protein (Fig. 3f, g and Extended Data Fig. 5). }}</ref>}}
|{{risk | level = low | align = ml|บางอย่างยังคงประสิทธิศักย์<wbr/><ref name="b117e484k"/>}}
|-
|{{sort |5|เอปซิลอน}}
|B.1.429, B.1.427
|—
|21C
|[[สหรัฐ]]
|{{dts |2020|03 | format = dmy | abbr = on}}
|{{dts |2021|03|17 | format = dmy | abbr = on}}<ref>{{cite news | last = Azad | first = Arman | title = Coronavirus strains first detected in California are officially 'variants of concern,' CDC says | url = https://edition.cnn.com/2021/03/17/health/california-variants-of-concern-cdc/index.html | work = CNN | date = 2021-03-17 | access-date = 2021-06-06}}</ref>
|L452R<ref name=":33" />
|{{risk | level = high | align = ml|{{Estimate |+20 | unit = % | mini = auto}} ({{val |19|-|24 | u = %}})<wbr/>{{efn-ua |
กย. 2020 - มค 2021 [[แคลิฟอร์เนีย]]<ref name="cdc-variants"/><ref>{{cite journal | last1 = Deng | first1 = X | last2 = Garcia-Knight | first2 = MA | last3 = Khalid | first3 = MM | last4 = Servellita | first4 = V | last5 = Wang | first5 = C | last6 = Morris | first6 = MK | last7 = Sotomayor-González | first7 = A | last8 = Glasner | first8 = DR | last9 = Reyes | first9 = KR | last10 = Gliwa | first10 = AS | last11 = Reddy | first11 = NP | last12 = C | first12 = Sanchez San Martin | last13 = Federman | first13 = S | last14 = Cheng | first14 = J | last15 = Balcerek | first15 = J | last16 = Taylor | first16 = J | last17 = Streithorst | first17 = JA | last18 = Miller | first18 = S | last19 = Kumar | first19 = GR | last20 = Sreekumar | first20 = B | last21 = Chen | first21 = PY | last22 = Schulze-Gahmen | first22 = U | last23 = Taha | first23 = TY | last24 = Hayashi | first24 = J | last25 = Simoneau | first25 = CR | last26 = McMahon | first26 = S | last27 = Lidsky | first27 = PV | last28 = Xiao | first28 = Y | last29 = Hemarajata | first29 = P | last30 = Green | first30 = NM | last31 = Espinosa | first31 = A | last32 = Kath | first32 = C | last33 = Haw | first33 = M | last34 = Bell | first34 = J | last35 = Hacker | first35 = JK | last36 = Hanson | first36 = C | last37 = Wadford | first37 = DA | last38 = Anaya | first38 = C | last39 = Ferguson | first39 = D | last40 = Lareau | first40 = LF | last41 = Frankino | first41 = PA | last42 = Shivram | first42 = H | last43 = Wyman | first43 = SK | last44 = Ott | first44 = M | last45 = Andino | first45 = R | last46 = Chiu | first46 = CY | display-authors = 6 | title = Transmission, infectivity, and antibody neutralization of an emerging SARS-CoV-2 variant in California carrying a L452R spike protein mutation | via = medRxiv | date = 2021-03-09 | pmid = 33758899 | pmc = 7987058 | doi = 10.1101/2021.03.07.21252647 | type = Preprint | url = https://www.medrxiv.org/content/10.1101/2021.03.07.21252647v1.full-text }}</ref>
ถูกอัลฟาแซงไปแล้ว<ref name="NYTimes 17May"/>}}}}
|{{risk | level = unknown | align = ml|''กำลังตรวจสอบ''}}
|{{risk | level = unknown | align = ml|''กำลังตรวจสอบ''}}
|{{risk | level = unknown | align = ml|''กำลังตรวจสอบ''}}
|{{risk | level = medium | align = ml|ลดลงปานกลาง<wbr/>{{efn-ua | name = sciencemag-20c|
1 กย. 2020 - 29 มค. แคลิฟอร์เนีย<ref name="CaliNews">{{cite news | last1 = Wadman | first1 = M | date = 2021-02-23 | title = California coronavirus strain may be more infectious - and lethal | url = https://www.sciencemag.org/news/2021/02/coronavirus-strain-first-identified-california-may-be-more-infectious-and-cause-more | doi = 10.1126/science.abh2101 | work = Science News | access-date = 2021-03-17}}</ref>}}}}
|{{risk | level = medium | align = ml|ลดลงปานกลาง<wbr/>{{efn-ua | name = sciencemag-20c}}}}
|{{risk | level = high | align = ml|บางชนิดลดลงโดยยังไม่สามารถกำหนดผลที่แน่ชัด}}
|-
|{{sort |4|[[#เดลตา|เดลตา]]}}
|B.1.617.2
|VOC‑21APR‑02<wbr/>
|21A
|[[อินเดีย]]
|{{dts |2020|10 | format = dmy | abbr = on}}
|{{dts |2021|05|06 | format = dmy | abbr = on}}<ref>{{cite techreport | type = Briefing | title = SARS-CoV-2 variants of concern and variants under investigation in England, technical briefing 10 | id = GOV-8226 | institution = Public Health England | date = 2021-05-07 | url = https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/984274/Variants_of_Concern_VOC_Technical_Briefing_10_England.pdf | format = PDF | access-date = 2021-06-06}}</ref>
|L452R, T478K, P681R<wbr/><ref name=20A_617/>
|{{risk | level = veryhigh | align = ml|{{Estimate |+64|26|113 | unit = % | mini = auto}} <small>เทียบกับอัลฟา</small>{{efn-ua |
3 มีค. - 17 พค. 2021 ประเทศอังกฤษ<ref name="phe-briefing15"/>
ผลงานศึกษาเบื้องต้นอีกงานในญี่ปุ่นพบว่า สายพันธุเดลตาติดต่อได้เพียง{{nowrap |ร้อยละ 23}} ยิ่งกว่าสายพันธุ์อัลฟา<ref>{{cite document | last1 = Ito | first1 = K | last2 = Piantham | first2 = C | last3 = Nishiura | first3 = H | date = 2021-06-15 | title = Predicted domination of variant Delta of SARS-CoV-2 before Tokyo Olympic games, Japan | url = https://www.medrxiv.org/content/10.1101/2021.06.12.21258835v1 | type = Preprint | work = medRxiv | doi = 10.1101/2021.06.12.21258835 | s2cid = 235437370 }}</ref>{{efn-ua | name = different-conditions|
ความแตกต่างอาจมาจากนโยบายและการรักษาที่แตกต่างกันในแต่ละพื้นที่ในเวลาที่ต่าง{{nbsp}}ๆ กัน มาจากสมรรถภาพของระบบสาธารณสุข และสายพันธุ์ต่าง{{nbsp}}ๆ ที่กำลังกระจายอยู่ในพื้นที่}}}}}}
|{{risk | level = veryhigh | align = ml|{{Estimate |+85|39|147 | unit = % | mini = auto}} <small>เทียบกับอัลฟา</small>{{efn-ua |
1 เมย. - 6 มิย. 2021 ใน[[ประเทศสกอตแลนด์]]<ref>{{cite journal | last1 = Sheikh | first1 = A | last2 = McMenamin | first2 = J | last3 = Taylor | first3 = B | last4 = Robertson | first4 = C | date = 2021-06-14 | title = SARS-CoV-2 Delta VOC in Scotland: demographics, risk of hospital admission, and vaccine effectiveness | url = https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)01358-1/abstract | journal = The Lancet | doi = 10.1016/S0140-6736(21)01358-1 | issn = 0140-6736 | pmid = 34139198}}</ref>}}}}
|{{risk | level = unknown | align = ml|''กำลังตรวจสอบ''}}
|{{risk | level = low | align = ml|ไม่มีหลักฐานว่าเปลี่ยน<wbr/><ref name="who-update-8june"/>}}
|{{risk | level = medium | align = ml|ลดลง<ref name="B.1.617 neutralization">{{cite journal | last1 = Yadav | first1 = PD | last2 = Sapkal | first2 = GN | last3 = Abraham | first3 = P | last4 = Ella | first4 = R | last5 = Deshpande | first5 = G | last6 = Patil | first6 = DY | last7 = Nyayanit | first7 = DA | last8 = Gupta | first8 = N | last9 = Sahay | first9 = RR | last10 = Shete | first10 = AM | last11 = Panda | first11 = S | last12 = Bhargava | first12 = B | last13 = Mohan | first13 = VK | display-authors = 6 | title = Neutralization of variant under investigation B.1.617 with sera of BBV152 vaccinees. | journal = Clinical Infectious Diseases | publisher = Oxford University Press | date = 2021-05-07 | issue = ciab411 | doi = 10.1093/cid/ciab411 | pmid = 33961693 | url = https://academic.oup.com/cid/advance-article-abstract/doi/10.1093/cid/ciab411/6271524 | biorxiv = 10.1101/2021.04.23.441101}}</ref><ref name="delta-neutralization"/>}}
|{{risk | level = medium | align = ml|ลดลงน้อย<ref name="who-update-8june"/><ref>{{cite techreport | type = Assessment | title = Risk assessment for SARS-CoV-2 variant Delta | id = GOV-8664 | institution = Public Health England | date = 2021-06-18 | url = https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/994761/18_June_2021_Risk_assessment_for_SARS-CoV-2_variant_DELTA.pdf | format = PDF | access-date = 2021-06-22}}</ref>{{efn-ua |วัคซีน Covaxin ลดลงปานกลาง<ref name="B.1.617 neutralization"/>}}}}
|{{risk | level = low | align = ml|บางชนิดคงประสิทธิศักย์<ref name="delta-neutralization">{{cite bioRxiv | last1 = Planas | first1 = D | last2 = Veyer | first2 = D | last3 = Baidaliuk | first3 = A | last4 = Staropoli | first4 = I | last5 = Guivel-Benhassine | first5 = F | last6 = Rajah | first6 = MM | last7 = Planchais | first7 = C | last8 = Porrot | first8 = F | last9 = Robillard | first9 = N | last10 = Puech | first10 = J | last11 = Prot | first11 = M | display-authors = 6 | date = 2021-05-27 | title = Reduced sensitivity of infectious SARS-CoV-2 variant B.1.617.2 to monoclonal antibodies and sera from convalescent and vaccinated individuals | biorxiv = 10.1101/2021.05.26.445838}}</ref>}}
|-
|{{sort |10|[[#แคปปา|แคปปา]]}}
|B.1.617.1
|VUI‑21APR‑01
|21B
|[[อินเดีย]]
|{{dts |2020|10 | format = dmy | abbr = on}}
|—
|L452R, E484Q, P681R<wbr/><ref>{{Cite news | last1 = Nuki | first1 = Paul | last2 = Newey | first2 = Sarah | date = 2021-04-16 | title = Arrival of India's 'double mutation' adds to variant woes, but threat posed remains unclear | language = en-GB | work = The Telegraph | url = https://www.telegraph.co.uk/global-health/science-and-disease/arrival-indias-double-mutation-adds-variant-woes-threat-posed/ | access-date = 2021-04-17 | issn = 0307-1235}}</ref>
|{{risk | level = unknown | align = ml|''กำลังตรวจสอบ''}}
|{{risk | level = unknown | align = ml|''กำลังตรวจสอบ''}}
|{{risk | level = unknown | align = ml|''กำลังตรวจสอบ''}}
|{{risk | level = unknown | align = ml|''กำลังตรวจสอบ''}}
|{{risk | level = medium | align = ml|ลดลงเล็กน้อย<wbr/><ref name="B.1.617 neutralization"/>}}
|{{risk | level = medium | align = ml|ลดลงเล็กน้อย<wbr/><ref name="B.1.617 neutralization"/>}}
|{{risk | level = medium | align = ml|อาจลดลง}}
|-
|{{sort |7|อีตา}}
|B.1.525
|VUI‑21FEB‑03
|21D
|[[ไนจีเรีย]]
|{{dts |2020|12|11 | format = dmy | abbr = on}}<ref>
{{cite web | url = https://cov-lineages.org/global_report_B.1.525.html | title = B.1.525 international lineage report | website = cov-lineages.org | publisher = Pango team | access-date = 2021-06-04}}</ref><ref name="qc-earliest">
{{cite web | type = Software issue | title = Date mismatch between international report and lineage description - cov-lineages/pangolin | url = https://github.com/cov-lineages/pangolin/issues/243 | website = GitHub | date = 2021-06-13 | access-date = 2021-06-14}}</ref>
|—
|E484K, F888L<wbr /><ref name="Pango B.1.525" />|E484K, F888L<wbr /><ref name="Pango B.1.5253">{{cite web | title = B.1.525 | url = https://cov-lineages.org/global_report_B.1.525.html | access-date = 2021-03-22 | website = cov-lineages.org | publisher = Pango team}}</ref>
|{{risk | level = unknown | align = ml|''กำลังตรวจสอบ''}}
|{{risk | level = unknown | align = ml|''กำลังตรวจสอบ''}}
|{{risk | level = unknown | align = ml|''กำลังตรวจสอบ''}}
|{{risk | level = unknown | align = ml|''กำลังตรวจสอบ''}}
|{{risk | level = medium | align = ml|อาจลดลง<ref name="cdc-variants"/>}}
|{{risk | level = medium | align = ml|อาจลดลง<ref name="cdc-variants"/>}}
|{{risk | level = medium | align = ml|อาจลดลง}}
|}
== ชื่อ ==
| 